Visitors can travel from Athens to Mesolongi by bus. There are several buses from Athens to Mesolongi, about 4-5 buses per day. Buses depart from Kifissos Bus Station in Athens and the trip takes about 4 hours, passing from the famous Rio-Antirrio cable bridge.
Travel to Mesolongi
Travel to Mesolongi, Greece: Visitors can travel to Mesolongi by car or bus. Here is travel information about buses and cars but also useful numbers, pdf guide.
Visitors can also access Mesolongi by car. The road trip from Athens to Mesolongi is about 4 hours. You take the road from Athens to Patra and then you pass the cable bridge of Rio-Antirio and you follow the signs to Mesolongi. The road from Athens until Corinth is very large and comfortable, however, after Corinth, it gets more narrow and has only one line per direction.
Useful numbers in Mesolongi: police station, hospital, taxis, bus services, museums and more